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MNK inhibitor 9

CAS No. 1889336-59-7

MNK inhibitor 9( —— )

Catalog No. M12960 CAS No. 1889336-59-7

MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MNK inhibitor 9
  • Note
    Research use only, not for human use.
  • Brief Description
    MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM).
  • Description
    MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM); displays excellent selectivity against a 53 kinase panel, with 4 kinases with IC50 <1 uM; inhibits eIF4E phosphorylation in KMS11-luc myeloma with IC50 of 0.6 nM, exhibits inhibition of cell proliferation in human multiple myeloma tumor cell line with EC50 of 1.7 uM; has good solubility and permeability, and is a suitable in vivo tool compound.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    MNK
  • Recptor
    MNK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1889336-59-7
  • Formula Weight
    471.569
  • Molecular Formula
    C25H29N9O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (S)-2-(5-Amino-6-(1-methyl-7-(3-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)pyrazin-2-yl)-N,N-dimethylisonicotinamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Han W, et al. J Med Chem. 2016 Apr 14;59(7):3034-45.
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